Our second emphasis is disease study in patients and to be modality independent. All too often, our industry has found that experimental models have little predictive value with respect to infectious disease research, which often results in the failure of human trials and escalating drug development costs.  Our Salt Lake research facilities allow us to isolate and leverage unconventional approaches, best suited to interdict a disease. While it is significantly more complicated to study disease in humans, we believe it is the only way to successfully develop human therapeutics.  Defining key elements of disease response in patient populations drives our R&D investment and the potential therapeutics we pursue.